Platelet Factor 4 human


Product # Platelet Factor 4 human (PF4-h)
Species human
Source Thrombocytes
Mol wt. 7.8 kDa (monomer); 31.2 kDa (tetramer)
UniProt # P02776
Purity > 98% (SDS-PAGE)
Product sizes 200 µg, 1mg (different sizes are available on request)
Quality control PF4/Heparin-ELISA (HIT-Test)*, PF4-ELISA, Western Blot, N-terminal sequencing and MALDI-TOF-MS
Physical form Lyophilized in PBS (0.22 µm filtered) carrier free,
Lyophilized in HBSS (0.22 µm Filter) carrier free,
Lyophilized in 1.6 M NaCl (0.22 µm Filter) carrier free
(different buffers are available on request)
Reconstitution Reconstitute carefully in A. dest. (1µl/µg PF4). Adjust the protein concentration with the chosen buffer. Do not vortex.
Shipping Ambient temperature
Storage Store dark in working aliquots at -20°C to -80°C.
Avoid repeated freezing and thawing.
Stability Lyophilisate is stable for at least 24 month.


Platelet Factor 4 (PF4; also known as CXCL4) is synthesized in megakaryocytes and platelets. The monomer of the chemokine consists of 70 amino acids resulting in a molecular weight of 7.8 kDa. Depending on the protein concentration and buffer conditions, PF4 appears as a mono-, di-, tri-, or tetramer. PF4 is biologically active in the tetrameric form, promotes blood coagulation and is also important in wound healing and inflammation. PF4, together with heparin (PF4-heparin complex) is an important antigen of antibodies inducing heparin-induced thrombocytopenia (HIT). Purified PF4 is used in several laboratory tests for the detection of HIT antibodies.

*The production of PF4 and its quality control is performed in collaboration with the Institute of Immunology and Transfusion Medicine, Department of Transfusion Medicine of the University Medicine Greifswald.

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SDS-Page (PF4 tetramers)
SDS-Page + Western Blot
Platelet Factor 4 -ELISA