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Publications:
- Blood August 4, 2011 vol. 118 no. 5 1395-1401,
Prepublished online June 9, 2011; DOI 10.1182/blood-2011-03-342857,
Andreas Greinacher, Birte Holtfreter, Krystin Krauel, Daniela Gätke, Claudia Weber, Till Ittermann, Sven Hammerschmidt, Thomas Kocher
Association of natural anti-platelet factor 4/heparin antibodies with periodontal disease
- Blood, 27 January 2011, Vol. 117, No. 4, pp. 1370-1378.,
Prepublished online October 19, 2010; DOI 10.1182/blood-2010-08-301424
Krystin Krauel, Christian Pötschke, Claudia Weber, Wolfram Kessler, Birgitt Fürll, Till Ittermann, Stefan Maier, Sven Hammerschmidt, Barbara M. Bröker, and Andreas Greinacher
Platelet factor 4 binds to bacteria inducing antibodies cross-reacting with the major antigen in heparin-induced thrombocytopenia
- Journal of Thrombosis and Haemostasis Volume 8, Issue 9, pages 2025–2031
Published Online: September 2010
A. Greinacher, T. Ittermann,J. Bagemühl, K. Althaus, B. Fürll, S. Selleng, N. Lubenow, S. Schellong, J. I. Sheppard, T.E. Warkentin
Heparin-induced thrombocytopenia: towards standardization of platelet factor 4/heparin antigen tests
- Nat Med. 2009 Dec 27. [Epub ahead of print]
Andreas Greinacher, Jan Wesche, Elke Hammer, Birgitt Fürll, Uwe Völker, Angelika Reil & Jürgen Bux
Published online: 27 December 2009 | doi:10.1038/nm.2070
Characterization of the human neutrophil alloantigen-3a.
- Transfusion. 2009 Aug 26. [Epub ahead of print]
Kathleen Selleng, Antje Schütt, Sixten Selleng, Theodore E. Warkentin, and Andreas Greinacher
Studies of the anti–platelet factor 4/heparin immune response: adapting the enzyme-linked immunosorbent spot assay for detection of memory B cells against complex antigens
- Nature Medicine 15, 97 - 103 (2008)
Published online: 4 January 2009
Rory R Koenen, Philipp von Hundelshausen, Irina V Nesmelova, Alma Zernecke, Elisa A Liehn, Alisina Sarabi, Birgit K Kramp, Anna M Piccinini, Søren R Paludan, M Anna Kowalska, Andreas J Kung, Tilman M Hackeng, Kevin H Mayo & Christian Weber
Disrupting functional interactions between platelet chemokines inhibits atherosclerosis in hyperlipidemic mice
- Journal of Thrombosis and Haemostasis Volume 6 Issue 12, Pages 2160 - 2167
Published Online: 3 Oct 2008
K. Krauel, B. Fürll, T. E. Warkentin, W. Weitschies, T. Kohlmann, J. I. Sheppard and A. Greinacher
Heparin-induced thrombocytopenia – therapeutic concentrations of danaparoid, unlike fondaparinux and direct thrombin inhibitors, inhibit formation of platelet factor 4–heparin complexes
- BLOOD, 15 August 2008 Volume 112, Number 4
Zhihua Xiao,1 Gian P. Visentin,2 Kannayakanahalli M. Dayananda,1 and Sriram Neelamegham1,3
Immune complexes formed following the binding of anti–platelet factor 4 (CXCL4) antibodies to CXCL4 stimulate human neutrophil activation and cell adhesion
- J Thromb Haemost 2007; 5: 235–41.
S . Schenk,A. El-Banayosy, M. Morshuis, L. Arusoglu, P. Eichler, N. Lubenow, G. Tendrich, R. Koerfer, A. Greinacher 1 and W. Prohaska
IgG classification of anti-PF4/heparin antibodies to identify patients with heparin-induced thrombocytopenia during mechanical circulatory support
- Arterioscler Thromb Vasc Biol. 2006;26:000-000.)
Andreas Greinacher, Manesh Gopinadhan, Jens-Uwe Günther, Mahmoud A. Omer-Adam, Ulrike Strobel, Theodore E. Warkentin, Georg Papastavrou, Werner Weitschies, Christiane A. Helm
Close Approximation of Two Platelet Factor 4 Tetramers by Charge Neutralization Forms the Antigens Recognized by HIT Antibodies
- Eur J Haematol 2006: 76: 420–426
Juhl D, Eichler P, Lubenow N, Strobel U, Wessel A, Greinacher A.
Incidence and clinical significance of anti-PF4/heparin antibodies of the IgG, IgM, and IgA class in 755 consecutive patient samples referred for diagnostic testing for heparin-induced thrombocytopenia.
- BLOOD, 1 February 2005 Volume 105, Number 3; 924-930
Blood First Edition Paper, prepublished online September 30, 2004; DOI 10.1182/blood-2004-06-2475
Philipp von Hundelshausen, Rory R Koenen, Markus Sack, Sebastian F Mause, Wencke Adriaens, Amanda EI Proudfoot, Tilman M Hackeng, and Christian Weber
Heterophilic interactions of Platelet Factor 4 and RANTES promote monocyte arrest on endothelium
- 46th Annual meeting of the GTH (Gesellschaft für Thrombose- und Hämostaseforschung) February 20-23, 2002, Erfurt
Eichler P. (1), Lubenow N. (1), Albrecht D. (1), Raschke R. (1), Hippe H.(2), Schröder D. (2), Greinacher A. (1)
(1) E.-M.-Arndt-Universität (Greifswald), (2) Chromatec (Greifswald)
Development of an in-house pf4/heparin elisa and comparison with the ID-H/pf4 antibody test (DIAMED) and further antigenic and functional assays for detection of HIT-antibodies
FDA-Studies:
Patents USA:
Patents Europa:
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